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Biospecimens Inventory

The biorepository comprises hundreds of thousands of unique donor cases of FFPE tissues with their original H&E slides, from all organ systems, and includes normal tissues, benign non-neoplastic pathologies and both benign and malignant tumors of all diagnoses (carcinomas, melanomas, lymphomas and leukemias; sarcomas; mesotheliomas). Specimens include large tumor reductive surgical excision specimens with generous tumor volume blocks, biopsies (endoscopic and core needle biopsies) and cytology specimens (both FNAs and exfoliative cytology brushings, washings, and lavages).  Matched benign tissue is available with the malignant tissues, for comparative genomic studies. All cases have detailed pathology related data, including tumor grade and stage, and many tumors have molecular data.

Control tissues:

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  1. All normal tissues available

  2. Resection tissue blocks positive for H. Pylori – with confirmatory H. pylori immunostains

  3. Resection tissue amyloid blocks

  4. Tonsils, for lymphoid marker positive controls

Malignancies by organ:

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Lung

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  1. Non small cell lung carcinoma – adenocarcinoma, squamous carcinoma, large cell carcinoma

  2. Small cell undifferentiated carcinoma

  3. Neuroendocrine carcinomas

  4. Metastases

  5. Sarcoma

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Head and Neck

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  1. Squamous carcinoma

  2. Salivary gland tumors including adenoid cystic carcinomas

  3. Tongue

  4. Metastases

  5. Sarcomas

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Thyroid

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      1. Papillary carcinoma

      2. Follicular neoplasms, adenomas and carcinomas

      3. Miscellaneous other

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Breast

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  1. Ductal carcinomas, in-situ and invasive, fully characterized for ER/PR/Her-2-Neu, and classified into luminal A, luminal B, triple negative/basal cell type and Her-2-Neu

  2. Lobular, in-situ and invasive, fully characterized for ER/PR/Her-2-Neu, and classified into luminal A, luminal B, triple negative/basal cell type and Her-2-Neu

  3. Metastases

  4. Sarcomas

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Stomach

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  1. Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type

  2. Neuroendocrine carcinomas

  3. Metastases

  4. Sarcomas

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Esophagus

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  1. Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type

  2. Squamous carcinoma

  3. Neuroendocrine carcinomas

  4. Sarcomas

​Small Bowel

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  1. Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type

  2. Neuroendocrine carcinomas

  3. Metastases

  4. Sarcomas

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Colon and rectum 

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  1. Adenocarcinoma, intestinal type, and mucinous/diffuse signet ring type, with MSI characterization - both MSI-H and MSI-S tumors available

  2. Neuroendocrine carcinomas 

  3. Sarcomas 

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Kidney and Urinary Bladder

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  1. Renal cell carcinoma, all subtypes

  2. Urothelial/transitional cell carcinomas

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Liver

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  1. Hepatocellular carcinoma

  2. Cholangiocarcinoma

  3. Metastases

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Pancreatic and Biliary

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  1. Adenocarcinoma

  2. Neuroendocrine carcinomas

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Skin

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  1. Melanoma

  2. Squamous carcinoma

  3. Basal cell carcinoma

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Brain

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  1. Astrocytomas including GBM

  2. Metastases

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Soft Tissue

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  1. Sarcomas, all subtypes including Ewings/PNET

  2. Plasmacytomas

  3. Metastases

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Hematopoietic Malignancies

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  1. Lymphomas, all subtypes

  2. Leukemias

  3. Multiple myeloma

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Miscellaneous other, varied sites and rare tumor types

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