Biospecimens Inventory

The biorepository comprises hundreds of thousands of unique donor cases of FFPE tissues with their original H&E slides, from all organ systems, and includes normal tissues, benign non-neoplastic pathologies and both benign and malignant tumors of all diagnoses (carcinomas, melanomas, lymphomas and leukemias; sarcomas; mesotheliomas). Specimens include large tumor reductive surgical excision specimens with generous tumor volume blocks, biopsies (endoscopic and core needle biopsies) and cytology specimens (both FNAs and exfoliative cytology brushings, washings, and lavages). Matched benign tissue is available with the malignant tissues, for comparative genomic studies. All cases have detailed pathology related data, including tumor grade and stage, and many tumors have molecular data.

Control tissues:

All normal tissues available
Resection tissue blocks positive for H. Pylori – with confirmatory H. pylori immunostains
Resection tissue amyloid blocks
Tonsils, for lymphoid marker positive controls

Malignancies by organ:

Lung

Non small cell lung carcinoma – adenocarcinoma, squamous carcinoma, large cell carcinoma
Small cell undifferentiated carcinoma
Neuroendocrine carcinomas
Metastases
Sarcoma

Head and Neck

Squamous carcinoma
Salivary gland tumors including adenoid cystic carcinomas
Tongue
Metastases
Sarcomas

Thyroid

1. Papillary carcinoma

2. Follicular neoplasms, adenomas and carcinomas

3. Miscellaneous other

Breast

Ductal carcinomas, in-situ and invasive, fully characterized for ER/PR/Her-2-Neu, and classified into luminal A, luminal B, triple negative/basal cell type and Her-2-Neu
Lobular, in-situ and invasive, fully characterized for ER/PR/Her-2-Neu, and classified into luminal A, luminal B, triple negative/basal cell type and Her-2-Neu
Metastases
Sarcomas

Stomach

Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type
Neuroendocrine carcinomas
Metastases
Sarcomas

Esophagus

Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type
Squamous carcinoma
Neuroendocrine carcinomas
Sarcomas

Small Bowel

Adenocarcinoma, intestinal type and mucinous/diffuse signet ring type
Neuroendocrine carcinomas
Metastases
Sarcomas

Colon and rectum

Adenocarcinoma, intestinal type, and mucinous/diffuse signet ring type, with MSI characterization - both MSI-H and MSI-S tumors available
Neuroendocrine carcinomas
Sarcomas

Kidney and Urinary Bladder